Manual Therapy
Volume 15, Issue 5 , Pages 434-444 , October 2010

Adverse events associated with the use of cervical manipulation and mobilization for the treatment of neck pain in adults: A systematic review

  • Lisa C. Carlesso

      Affiliations

    • Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    • Corresponding Author InformationCorresponding author. Manual Concepts Physiotherapy, 31 Farley Dr., Guelph, ON, Canada N1H 3C2. Tel.: +1 519 766 7774; fax: +1 519 766 9689.
    • Lisa Carlesso is supported by a Strategic Training Program in Rehabilitation Research from the Canadian Institute of Health Research Institute of Musculoskeletal Health and Arthritis.
    • ,
  • Anita R. Gross

      Affiliations

    • School of Rehabilitation Science, & Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    • ,
  • P. Lina Santaguida

      Affiliations

    • Evidence-Based Practice Unit, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    • ,
  • Stephen Burnie

      Affiliations

    • Canadian Memorial Chiropractic College, Toronto, Ontario, Canada
    • ,
  • Sandra Voth

      Affiliations

    • Physical Therapist, Private Practice, Lethbridge, Alberta, Canada
    • ,
  • Jackie Sadi

      Affiliations

    • School of Physical Therapy, University of Western Ontario, London, Ontario, Canada

Received 10 August 2009 ,Revised 14 November 2009 ,Accepted 11 February 2010.

References 

  1. Bronfort G, Evans R, Nelson B, Aker PD, Goldsmith CH, Vernon H. A randomized clinical trial of exercise and spinal manipulation for patients with chronic neck pain. Spine. 2001;26(7):788–797discussion 798–99
  2. Buitenhuis J, de Jong PJ, Jaspers JP, Groothoff JW. Work disability after whiplash: a prospective cohort study. Spine. 2009;34(3):262–267
  3. Cagnie B, Vinck E, Beernaert A, Cambier D. How common are side effects of spinal manipulation and can these side effects be predicted?. Manual Therapy. 2004;9(3):151–156
  4. Carnes D, Mullinger B, Underwood M. Defining adverse events in manual therapies: a modified Delphi consensus study. Manual Therapy. 2010;15(1):2–6
  5. Cassidy JD, Boyle E, Cote P, He Y, Hogg-Johnson S, Silver FL, et al. Risk of vertebrobasilar stroke and chiropractic care: results of a population-based case–control and case-crossover study. Spine. 2008;33(4 Suppl):S176–S183
  6. Chen L, Zhand XL, Ding H, Tao YQ, Zhan HS. Comparative study on effects of manipulation treatment and transcutaneous electrical nerve stimulation on patients with cervicogenic headache. Journal of Chinese Integrative Medicine. 2007;5(4):403–406
  7. Cleland JA, Childs JD, McRae M, Palmer JA, Stowell T. Immediate effects of thoracic manipulation in patients with neck pain: a randomized clinical trial. Manual Therapy. 2005;10(2):127–135
  8. Cleland JA, Glynn P, Whitman JM, Eberhart SL, MacDonald C, Childs JD. Short-term effects of thrust versus nonthrust mobilization/manipulation directed at the thoracic spine in patients with neck pain: a randomized clinical trial. Physical Therapy. 2007;87(4):431–440
  9. Cote P, Cassidy JD, Carroll LJ, Kristman V. The annual incidence and course of neck pain in the general population: a population-based cohort study. Pain. 2004;112(3):267–273
  10. Cote P, van der Velde G, Cassidy JD, Carroll LJ, Hogg-Johnson S, Holm LW, et al. Bone, Joint Decade-2010 Task Force on Neck, P, Its Associated, D. The burden and determinants of neck pain in workers: results of the Bone and Joint Decade 2000–2010 Task Force on neck pain and its associated disorders. Spine (Phila Pa 1976). 2008;33(4 Suppl):S60–S74
  11. Critical Appraisal Skills Programme, CASP . Available at: http://www.phru.nhs.uk/Pages/PHD/resources.htm2004;[accessed 15.02.09]
  12. Di Fabio RP. Manipulation of the cervical spine: risks and benefits. Physical Therapy. 1999;79(1):50–65
  13. Dziedzic K, Hill J, Lewis M, Sim J, Daniels J, Hay EM. Effectiveness of manual therapy or pulsed shortwave diathermy in addition to advice and exercise for neck disorders: a pragmatic randomized controlled trial in physical therapy clinics. Arthritis and Rheumatism. 2005;53(2):214–222
  14. Ernst E. Adverse effects of spinal manipulation: a systematic review. Journal of the Royal Society of Medicine. 2007;100(7):330–338
  15. Ernst E. Life-threatening complications of spinal manipulation. Stroke. 2001;32(3):809–810
  16. Ernst E. Manipulation of the cervical spine: a systematic review of case reports of serious adverse events, 1995–2001. Medical Journal of Australia. 2002;176(8):376–380
  17. Evans R, Bronfort G, Bittell S, Anderson AV. A pilot study for a randomized clinical trial assessing chiropractic care, medical care, and self-care education for acute and subacute neck pain patients. Journal of Manipulative and Physiological Therapeutics. 2003;26(7):403–411
  18. Fernandez-De-Las-Penas C, Fernandez-Carnero J, Fernandez AP, Lomas-Vega R, Miangolarra-Page JC. Dorsal manipulation in whiplash injury treatment: a randomized controlled trial. Journal of Whiplash and Related Disorders. 2004;3(2):55–72
  19. Fleiss JL, Cohen J. The equivalence of weighted kappa and the intraclass correlation coefficient as measures of reliability. Educational and Psychological Measurement. 1973;33:613–619
  20. Gonzalez-Iglesias J, Fernandez-de-las-Penas C, Cleland JA, Gutierrez-Vega Mdel R. Thoracic spine manipulation for the management of patients with neck pain: a randomized clinical trial. Journal of Orthopaedic and Sports Physical Therapy. 2009;39(1):20–27
  21. Gouveia LO, Castanho P, Ferreira JJ. Safety of chiropractic interventions: a systematic review. Spine. 2009;34(11):E405–E413
  22. Gross A, Goldsmith C, Hoving J, Haines T, Peloso P, Aker P, et al. Conservative management of mechanical neck disorders: a systematic review. Journal of Rheumatology. 2007;34(5):1083–1102
  23. Gross AR, Hoving JL, Haines TA, Goldsmith CH, Kay T, Aker P, et al. Manipulation and mobilisation for mechanical neck disorders. Cochrane Database Syst Rev. 2004;(1):p. CD004249
  24. Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ. What is “quality of evidence” and why is it important to clinicians?. British Medical Journal. 2008;336(7651):995–998
  25. Guyatt GH, Rennie D, Meade MO, Cook DJ. Users' guides to the medical literature. A manual for evidence based clinical practice. 2nd ed.. McGraw-Hill; 2002;
  26. Guzman J, Hurwitz EL, Carrol LJ, Haldeman S, Cote P, Carragee EJ, et al. A new conceptual model of neck pain: linking onset, course, and care: the bone and joint decade 2000–2010 Task Force on neck pain and its associated disorders. Spine. 2008;33(4S):S14–S23
  27. Haas M, Groupp E, Aickin M, Fairweather A, Ganger B, Attwood M, et al. Dose response for chiropractic care of chronic cervicogenic headache and associated neck pain: a randomized pilot study. Journal of Manipulative and Physiological Therapeutics. 2004;27(9):547–553
  28. Haas M, Groupp E, Panzer D, Partna L, Lumsden S, Aickin M. Efficacy of cervical endplay assessment as an indicator for spinal manipulation. Spine. 2003;28(11):1091–1096
  29. Hakes JK, Viscusi WK. Dead reckoning: demographic determinants of the accuracy of mortality risk perceptions. Risk Analysis. 2004;24(3):651–664
  30. Haldeman S, Carey P, Townsend M, Papadopoulos C. Clinical perceptions of the risk of vertebral artery dissection after cervical manipulation: the effect of referral bias. Spine Journal. 2002;2(5):334–342
  31. Haneline MT, Croft AC, Frishberg BM. Association of internal carotid artery dissection and chiropractic manipulation. Neurologist. 2003;9(1):35–44
  32. Higgins J, Green Se. Cochrane handbook for systematic reviews of interventions. Version 5.0.1 The Cochrane Collaboration; September 2008;
  33. Hogg-Johnson S, van der Velde G, Carroll LJ, Holm LW, Cassidy JD, Guzman J, et al. The burden and determinants of neck pain in the general population: results of the Bone and Joint Decade 2000–2010 Task Force on Neck Pain and its associated disorders. Spine. 2008;33(4 Suppl):S39–S51
  34. Hoving JL, Koes BW, De Vet HCW, Van der Windt DAWM, Assendelft WJJ, Van Mameren H, et al. Manual therapy, physical therapy, or continued care by a general practitioner for patients with neck pain: a randomized, controlled trial. Annals of Internal Medicine. 2002;136(10):713–722
  35. Hurwitz EL, Aker PD, Adams AH, Meeker WC, Shekelle PG. Manipulation and mobilization of the cervical spine. A systematic review of the literature. Spine. 1996;21(15):1746–1759discussion 1759–60
  36. Hurwitz EL, Morgenstern H, Vassilaki M, Chiang LM. Adverse reactions to chiropractic treatment and their effects on satisfaction and clinical outcomes among patients enrolled in the UCLA Neck Pain Study. Journal of Manipulative and Physiological Therapeutics. 2004;1:16–25
  37. Jull G, Trott P, Potter H, Zito G, Niere K, Shirley D, et al. A randomized controlled trial of exercise and manipulative therapy for cervicogenic headache. Spine. 2002;27(17):1835–1843
  38. Kanlayanaphotporn R, Chiradejnant A, Vachalathiti R. The immediate effects of mobilisation technique on pain and range of motion in patients presenting with unilateral neck pain: a randomized controlled trial. Archives of Physical Medicine and Rehabilitation. 2009;90:187–192
  39. Linton SJ, Hellsing AL, Hallden K. A population-based study of spinal pain among 35–45-year-old individuals. Prevalence, sick leave, and health care use. Spine. 1998;23(13):1457–1463
  40. Mann T, Refshauge KM. Causes of complications from cervical spine manipulation. Australian Journal of Physiotherapy. 2001;47(4):255–266
  41. Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al. Expenditures and health status among adults with back and neck problems. Journal of the American Medical Association. 2008;299(6):656–664
  42. Mayor EE, Perez GL, Martin YP, Del Barco AA, Fuertes RR, Requejo CS. Randomised clinical trial for primary care patients with neck pain: manual therapy versus electrical stimulation. Atencion Primaria. 2008;40(7):337–343
  43. McReynolds TM, Sheridan BJ. Intramuscular ketorolac versus osteopathic manipulative treatment in the management of acute neck pain in the emergency department: a randomized clinical trial. Journal of the American Osteopathic Association. 2005;105(2):57–68
  44. Olesen J. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalgia. 1988;8(7):61–62
  45. Olesen J, Gobel H. ICD-10 Guide for Headaches. Guide to the classification, diagnosis and assessment of headaches in accordance with the tenth revision of the International classification of diseases and related health problems and its application to neurology. Cephalgia. 1997;17(Suppl. 19):29–30
  46. Pitrou I, Boutron I, Ahmad N, Ravaud P. Reporting of safety results in published reports of randomized controlled trials. Archives of Internal Medicine. 2009;169(19):1756–1761
  47. Rivett DA, Reid D. Risk of stroke for cervical spine manipulation in New Zealand. New Zealand Journal of Physiotherapy. 1998;26(2):14–17
  48. Rothwell DM, Bondy SJ, Williams JI. Chiropractic manipulation and stroke: a population-based case–control study. Stroke. 2001;32(5):1054–1060
  49. Rubinstein SM, Leboeuf-Yde C, Knol DL, de Koekkoek TE, Pfeifle CE, van Tulder MW. The benefits outweigh the risks for patients undergoing chiropractic care for neck pain: a prospective, multicenter, cohort study. Journal of Manipulative and Physiological Therapeutics. 2007;30(6):408–418
  50. Santaguida P, Raina P, Ismaila A. McMaster quality assessment scale of harms (McHarm) for primary studies. Available at: 2004;http://hiru.mcmaster.ca/epc//mcharm.pdf[accessed 15.02.09]
  51. Schumacher HR, Klippel JH, Koopman WJe. Primer on the rheumatic diseases. 10th ed.. Atlanta: Arthritis Foundation; 1993;
  52. Sjaastad O, Fredriksen TA, Pfaffenrath V. Cervicogenic headache: diagnostic criteria. Headache. 1990;30(11):725–726
  53. Smith WS, Johnston SC, Skalabrin EJ, Weaver M, Azari P, Albers GW, et al. Spinal manipulative therapy is an independent risk factor for vertebral artery dissection. Neurology. 2003;60(9):1424–1428
  54. Spitzer W, Leblanc F, Dupuis M. Scientific approach to the assessment and management of activity related spinal disorders. Spine. 1987;7:S1–S59
  55. Spitzer WO, Skovron ML, Salmi LR, Cassidy JD, Duranceau J, Suissa S, et al. Scientific monograph of the Quebec Task Force on whiplash-associated disorders: redefining “whiplash” and its management. Spine (Phila Pa 1976). 1995;20(8 Suppl):1S–73S
  56. Strunk RG, Hondras MA. A feasibility study assessing manual therapies to different regions of the spine for patients with subacute or chronic neck pain. Journal of Chiropractic Medicine. 2008;7(1):1–8
  57. Sweeting M, Sutton A, Lambert P. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Statistics in Medicine. 2004;23:1351–1375
  58. The Nordic Cochrane Centre . Review manager (RevMan) [computer program]. Version 5.0 Copenhagen: The Cochrane Collaboration; 2008;
  59. Thiel HW, Bolton JE, Docherty S, Portlock JC. Safety of chiropractic manipulation of the cervical spine: a prospective national survey. Spine. 2007;32(21):2375–2378discussion 2379
  60. Tomlinson PJ, Gargan MF, Bannister GC. The fluctuation in recovery following whiplash injury 7.5-year prospective review. Injury. 2005;36(6):758–761
  61. Tsang R, Colley L, Lynd LD. Inadequate statistical power to detect clinically significant differences in adverse event rates in randomized controlled trials. Journal of Clinical Epidemiology. 2009;62(6):609–616
  62. Zhi LX, Feng CW, Tu CY. Controlled randomized trial on therapeutic effects of acupotomy-injection combined with Feng's spinal manipulation (FSM) for cervical spondylotic radiculopathy. Zhongguo Gushang. 2008;21(6):421–424

PII: S1356-689X(10)00033-0

doi: 10.1016/j.math.2010.02.006

Manual Therapy
Volume 15, Issue 5 , Pages 434-444 , October 2010

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