Manual Therapy
Volume 15, Issue 4 , Pages 355-363 , August 2010

Adverse events and manual therapy: A systematic review

  • Dawn Carnes

      Affiliations

    • Barts and The London School of Medicine and Dentistry, Centre for Health Sciences, 2 Newark St, London E1 2AT, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 20 7882 2546.
  • ,
  • Thomas S. Mars

      Affiliations

    • European School of Osteopathy, Boxley House, Boxley, Maidastone, Kent ME14 3DZ, UK
  • ,
  • Brenda Mullinger

      Affiliations

    • European School of Osteopathy, Boxley House, Boxley, Maidastone, Kent ME14 3DZ, UK
  • ,
  • Robert Froud

      Affiliations

    • Barts and The London School of Medicine and Dentistry, Centre for Health Sciences, 2 Newark St, London E1 2AT, UK
  • ,
  • Martin Underwood

      Affiliations

    • Warwick Medical School, Gibbetts Hill, Coventry, CV4 7AL, UK

Received 11 August 2009 ,Revised 9 December 2009 ,Accepted 17 December 2009.

References 

  1. Airaksinen O, Hildenbrandt J, Mannion A, Ursin H, Brox J, Klaber-Moffet J, et al. European guidelines for the management of chronic non-specific low back pain. European Commission; 2004;http://www.backpaineurope.org/web/files/WG2_Guidelines.pdf
  2. Altman DG. Better reporting of randomised controlled trials: the CONSORT statement. BMJ. 1996;313:570–571
  3. Barrett AJ, Breen AC. Adverse effects of spinal manipulation. Journal of the Royal Society of Medicine. 2000;93(5):258–259
  4. Bove G, Nilsson N. Spinal manipulation in the treatment of episodic tension-type headache: a randomized controlled trial. JAMA. 1998;280(18):1576–1579
  5. Bronfort G, Evans R, Aker P, Goldsmith C, Vernon H. A randomized clinical trial of exercise and spinal manipulation for patients with chronic neck pain. Spine. 2001;26(7):788–797
  6. Burton K, Tillotson M, Cleary J. Single blind randomised controlled trial of chemonucleolysis and manipulation in the treatment of symptomatic lumbar disc herniation. European Spine Journal. 2000;9:202–207
  7. Cagnie B, Vinck E, Beernaert A, Cambier D. How common are side effects of spinal manipulation and can these side effects be predicted?. Manual Therapy. 2004;9(3):151–156
  8. Carnes D, Mullinger B, Underwood M. Defining adverse events in manual therapies: a modified Delphi consensus study. Manual Therapy. 2010;15(1):2–6
  9. Cashley MC, Cashley M, McWilliam R, Steen L. BISIMAN study: the background incidence if stroke in manipulation in the UK. Clinical Chiropractic. 2008;
  10. Cassidy JD, Boyle E, Côté P, He Y, Hogg-Johnson S, Silver FL, et al. Risk of vertebrobasilar stroke and chiropractic care: results of a population-based case-control and case-crossover study. Spine. 2008;33(Suppl. 4):S176–S183
  11. Cherkin DC, Eisenberg D, Sherman KJ, Barlow W, Kaptchuk TJ, Street J, et al. Randomized trial comparing traditional Chinese medical acupuncture, therapeutic massage, and self-care education for chronic low back pain. 2001;161:1081–8.
  12. Cleland J, Glynn P, Whitman J, Eberhart S, MacDonald C, Childs JP. Short term effects of thrust vs non-thrust mobilisation/manipulation directed at the thoracic spine in patients with neck pain: a randomised controlled trial. Physical Therapy. 2007;87(4):431–440
  13. Clopper C, Pearson S. The use of confidence or fiducial limits illustrated in the case of the binomial. Biometrika. 1934;26:404–413
  14. Dabbs V, Lauretti WJ. A risk assessment of cervical manipulation vs. NSAIDs for the treatment of neck pain. Journal of Manipulative & Physiological Therapeutics. 1995;18(8):530–536
  15. Ernst E. Manipulation of the cervical spine: a systematic review of case reports of serious adverse events, 1995–2001. The Medical Journal of Australia. 2002;176(8):376–380
  16. Ernst E. Prospective investigations into the safety of spinal manipulation. Journal of Pain and Symptom Manage. 2001;21(3):238–242
  17. Evans DW, Breen AC. A biomechanical model for mechanically efficient cavitation production during spinal manipulation: prethrust position and the neutral zone. Journal of Manipulative & Physiological Therapeutics. 2006;29(1):72–82
  18. Evans R, Bronfort G, Bittell S, Anderson AV. A pilot study for a randomized clinical trial assessing chiropractic care, medical care, and self-care education for acute and sub-acute neck pain patients. Journal of Manipulative & Physiological Therapeutics. 2003;26(7):403–411
  19. Ferreira ML, Ferreira PH, Latimer J, Herbert RD, Hodges PW, Jennings MD, et al. Comparison of general exercise, motor control exercise and spinal manipulative therapy for chronic low back pain: a randomized trial. Pain. 2007;131(1–2):31–37
  20. Garner MJ, Aker P, Balon J, Birmingham M, Moher D, Keenan D, et al. Chiropractic care of musculoskeletal disorders in a unique population within Canadian community health centres. Journal of Manipulative & Physiological Therapeutics. 2007;30(3):165–170
  21. Giles LG, Muller R. Chronic spinal pain syndromes: a clinical pilot trial comparing acupuncture, a non-steroidal anti-inflammatory drug, and spinal manipulation. Journal of Manipulative & Physiological Therapeutics. 1999;22(6):376–381
  22. Giles LG, Muller R. Chronic spinal pain: a randomized clinical trial comparing medication, acupuncture, and spinal manipulation. Spine. 2003;28(14):1490–1502
  23. Haas M, Goldberg B, Aickin M, Ganger B, Attwood M. A practice-based study of patients with acute and chronic low back pain attending primary care and chiropractic physicians: two-week to 48-month follow-up. Journal of Manipulative & Physiological Therapeutics. 2004;27(3):160–169
  24. Hancock MJ, Maher CG, Latimer J, McLachlan A, Cooper CW, Day RO, et al. Assessment of diclofenac or spinal manipulative therapy, or both, in addition to recommended first-line treatment for acute low back pain: a randomised controlled trial. Lancet. 2007;370(9599):1638–1643
  25. Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right?. JAMA. 1983;249:1743–1745
  26. Hawk C, Long CR, Rowell RM, Gudavalli MR, Jedlicka J. A randomized trial investigating a chiropractic manual placebo: a novel design using standardized forces in the delivery of active and control treatments. Journal of Alternative & Complementary Medicine. 2005;11(1):109–117
  27. Hawk C, Rupert RL, Colonvega M, Boyd J, Hall S. Comparison of bioenergetic synchronization technique and customary chiropractic care for older adults with chronic musculoskeletal pain. Journal of Manipulative & Physiological Therapeutics. 2006;29(7):540–549
  28. Hay EM, Mullis R, Lewis M, Vohora K, Main CJ, Watson P, et al. Comparison of physical treatments versus a brief pain-management programme for back pain in primary care: a randomised clinical trial in physiotherapy practice. Lancet. 2005;365(9476):2024–2030
  29. Higgins J, Thompson S, Deeks J, Altman D. Measuring inconsistency in meta analyses. BMJ. 6th Sept 2003;327:557–560
  30. Hoeksma HL, Dekker J, Ronday K, Heering A, van der Lubbe N, Vel C, et al. Comparison of manual therapy and exercise therapy in osteoarthritis of the hip: a randomized clinical trial. Arthritis & Rheumatism. 2004;51(5):722–729
  31. Hondras MA, Long CR, Brennan PC. Spinal manipulative therapy versus a low force mimic manoeuvre for women with primary dysmenorrhea: a randomized, observer-blinded, clinical trial. Pain. 1999;81(1–2):105–114
  32. Hoving JL, de Vet HC, van der Windt D, Assendelft W, van Mameren H, Deville W, et al. Manual therapy, physical therapy, or continued care by the general practitioner for patients with neck pain: long-term results from a pragmatic randomized clinical trial. Clinical Journal of Pain. 2006;22(4):370–377
  33. Hoving JL, Koes BW, de vet H, van der Windt D, Assendelft W, van Mameren H, et al. Manual therapy, physical therapy, or continued care by a general practitioner for patients with neck pain. A randomized, controlled trial. Annals of Internal Medicine. 2002;136(10):713–722
  34. Hsieh CY, Adams AH, Tobis J, Hong C, Danielson C, Platt K, et al. Effectiveness of four conservative treatments for subacute low back pain: a randomized clinical trial. Spine. 2002;27(11):1142–1148
  35. Hurwitz EL, Morgenstern H, Harber P, Kominski GF, Belin TR, Yu F, et al. Second prize: the effectiveness of physical modalities among patients with low back pain randomized to chiropractic care: findings from the UCLA low back pain study. Journal of Manipulative & Physiological Therapeutics. 2002;25(1):10–20
  36. Hurwitz EL, Morgenstern H, Kominski GF, Yu F, Chiang L. A randomized trial of chiropractic and medical care for patients with low back pain: eighteen-month follow-up outcomes from the UCLA low back pain study. Spine. 2006;31(6):611–621
  37. Hurwitz EL, Morgenstern H, Vassilaki M, Chiang L. Adverse reactions to chiropractic treatment and their effects on satisfaction and clinical outcomes among patients enrolled in the UCLA neck pain study. Journal of Manipulative & Physiological Therapeutics. 2004;27(1):16–25
  38. Hurwitz EL, Morgenstern H, Vassilaki M, Chiang L. Frequency and clinical predictors of adverse reactions to chiropractic care in the UCLA neck pain study. Spine. 2005;30(13):1477–1484
  39. Jull G, Trott P, Potter H, Zito G, Niere K, Shirley D, et al. A randomized controlled trial of exercise and manipulative therapy for cervicogenic headache. Spine. 2002;27(17):1835–1843
  40. Kerry R, Taylor AJ, Mitchell J, McCarthy C. Cervical arterial dysfunction and manual therapy: a critical literature review to inform professional practice. Manual Therapy. 2008;13(4):278–288
  41. Koes BW, Bouter LM, van der Heijden , Geert JMG. Methodological quality of randomised clinical trials on treatment efficacy in low back pain. Spine. 1995;20(2):228–235
  42. Leboeuf-Yde C, Hennius B, Rudberg E, Leufvenmark P, Thunman M. Side effects of chiropractic treatment: a prospective study. Journal of Manipulative & Physiological Therapeutics. 1997;20(8):511–515
  43. Nelson CF, Bronfort G, Evans R, Boline P, Goldsmith C, Anderson AV. The efficacy of spinal manipulation, amitriptyline and the combination of both therapies for the prophylaxis of migraine headache. Journal of Manipulative & Physiological Therapeutics. 1998;21(8):511–519
  44. NICE Guidelines (UK). Low back pain – early management of persistent non specific low back pain (CG88) May 2009.
  45. Oliphant D. Safety of spinal manipulation in the treatment of lumbar disk herniations: a systematic review and risk assessment. Journal of Manipulative & Physiological Therapeutics. 2004;27(3):197–210
  46. Plaugher G, Long CR, Alcantara J, Silveus AD, Wood H, Loton K, et al. Practice-based randomized controlled-comparison clinical trial of chiropractic adjustments and brief massage treatment at sites of subluxation in subjects with essential hypertension: pilot study. Journal of Manipulative & Physiological Therapeutics. 2002;25(4):221–239
  47. Rubinstein SM, Leboeuf-Yde C, Knol DL, de Koekkoek TE, Pfeifle CE, van Tulder ME. The benefits outweigh the risks for patients undergoing chiropractic care for neck pain: a prospective, multicenter, cohort study. Journal of Manipulative & Physiological Therapeutics. 2007;30(6):408–418
  48. Rubinstein SM, Peerdeman SM, Van Tulder MW, Riphagen I, Haldeman S. A systematic review of the risk factors for cervical artery dissection. Stroke. 2005;36:1575–1580
  49. Rubinstein SM. Adverse events following chiropractic care for subjects with neck pain. PhD Thesis. EMGO Institute, Netherlands; 2008 [chapter 8. General Discussion]. ISBN/EAN: 978-90-9023102-0.
  50. Santilli V, Beghi E, Finucci S. Chiropractic manipulation in the treatment of acute back pain and sciatica with disc protrusion: a randomized double-blind clinical trial of active and simulated spinal manipulations. Spine. 2006;6(2):131–137
  51. Sawyer CE, Evans RL, Boline P, Branson R, Spicer A. A feasibility study of chiropractic spinal manipulation versus sham spinal manipulation for chronic otitis media with effusion in children. Journal of Manipulative & Physiological Therapeutics. 1999;22(5):292–298
  52. Senstad O, Leboeuf-Yde C, Borchgrevink C. Predictors of side effects to spinal manipulative therapy. Journal of Manipulative & Physiological Therapeutics. 1996;19(7):441–445
  53. Senstad O, Leboeuf-Yde C, Borchgrevink C. Side-effects of chiropractic spinal manipulation: types frequency, discomfort and course. Scandinavian Journal of Primary Health Care. 1996;14(1):50–53
  54. Skargren EI, Carlsson PG, Oberg BE. One-year follow-up comparison of the cost and effectiveness of chiropractic and physiotherapy as primary management for back pain. Subgroup analysis, recurrence, and additional health care utilization. Spine. 1998;23(17):1875–1883discussion 1884
  55. Skargren EI, Oberg BE, Carlsson PG, Gade M. Cost and effectiveness analysis of chiropractic and physiotherapy treatment for low back and neck pain. Six-month follow-up. Spine. 1997;22(18):2167–2177
  56. Stevinson C, Honan W, Ernst E. Neurological complications of cervical spine manipulation. Journal of the Royal Society of Medicine. March 2001;107–110
  57. Strunk RG, Hondras MA. A feasibility study assessing manual therapies to different regions of the spine for patients with subacute or chronic neck pain. Journal of Chiropractic Medicine. 2008;7(1):1–8
  58. Thiel HW, Bolton JE, Docherty S, Portlock CJ. Safety of chiropractic manipulation of the cervical spine: a prospective national survey. Spine. 2007;32(21):2375–2378
  59. Thiel H, Bolton J. The reporting of patient safety incidents—first experiences with the chiropractic reporting and learning system (CRLS): a pilot study. Clinical Chiropractic. 2006;9(3):139–149
  60. Tuchin PJ, Pollard H, Bonello R. A randomized controlled trial of chiropractic spinal manipulative therapy for migraine. Journal of Manipulative & Physiological Therapeutics. 2000;23(2):91–95
  61. UK BEAM team . United Kingdom back pain exercise and manipulation (UK BEAM) randomised trial: effectiveness of physical treatments for back pain in primary care. British Medical Journal. 2004;329(7479):1377–1381
  62. Vicenzino B, Paungmali A, Buratowski S, Wright A. Specific manipulative therapy treatment for chronic lateral epicondylalgia produces uniquely characteristic hypoalgesia. Manual Therapy. 2001;6(4):205–212
  63. Williams NH, Wilkinson C, et al. Randomized osteopathic manipulation study (ROMANS): pragmatic trial for spinal pain in primary care. Family Practice. 2003;20(6):662–669

PII: S1356-689X(09)00211-2

doi: 10.1016/j.math.2009.12.006

Manual Therapy
Volume 15, Issue 4 , Pages 355-363 , August 2010